This is what a lot of people have been waiting for; so make sure you give it a careful read.
In an interview for Billboard titled John Frusciante Q&A: On His Electronic Evolution and Why He's Done With Rock Bands, the maestro has opened up about how and why he decided to leave the Red Hot Chili Peppers in the middle of the post-Stadium Arcadium tour break. He also admitted not to be interested in touring his music anymore, as entertaining people and being a performer is apparently "not his thing".
Furthermore, he also said that he's been making hip-hop music for the past six months, collaborating with Black Knights; which has been his purest collaboration so far. He believes that hip-hop, just like rock, can absorb any other music style.
Here's a sample answer
You play so many. Have any ever intimidated you?
I bought a clarinet, and I wanted to learn how to play that but it interfered with my singing. And I think there would be a time period if I learned it where it would make my throat tense, at least briefly, until I learned how to breathe properly. So yeah, I’ve had this clarinet sitting around for, like, a year and haven’t learned it. You know, that’s the beauty of the technology of sampling: You can play any instrument or any combination of instruments. You basically have the history of recorded music to play as your instrument. And I’m pretty adept at that. So there’s really no need to learn how to play other instruments since I can do that.